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This gene encodes a transcription factor that belongs for the homeobox gene spouse and children. Genes of the family are hugely conserved between vertebrates and important for vertebrate embryonic progress. This gene has been implicated in fetal skin improvement and cutaneous regeneration.

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In mice, an identical gene was demonstrated to exhibit temporal and spatial colinearity in the primary physique axis in the embryo, but wasn't expressed from the secondary axes, which indicates functions in physique patterning together the axis. This gene and also other HOXB genes kind a gene cluster on chromosome seventeen from the 17q21-22 area.[6]

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